KMID : 1007520080170040870
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Food Science and Biotechnology 2008 Volume.17 No. 4 p.870 ~ p.872
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Anticoagulant Activity of Sulfated Barley ¥â-Glucan
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Bae In-Young
Chang Yun-Jeoung Kim Hye-Won Lee Hyeon-Gyu
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Abstract
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Barley ¥â-Glucan was subjected to chemical modification and the anticoagulant activity of the derivative was investigated. The barley ¥â-Glucan was successfully sulfated, showing the degree of substitution calculated by elemental analysis of 0.40. In addition, the Fourier transform infrared (FT-IR) spectra of the derivative confirmed the sulfation, which generated two new absorption bands at 1,250/cm (S=O) and 810/cm (C-O-S) compared to the native. Specially, the anticoagulant activity of barley ¥â-Glucan was created by sulfation, which increased in a concentration-dependent manner. This result demonstrated that the incorporation of sulfate groups into the ¥â-Glucan structure added a blood clotting prevention effect.
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KEYWORD
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barley B-glucan, sulfation, anticoagulant activity
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